Spotlight on Vitamin C for
from LaCrista News, Vol. 3, Issue 2
Our mission is to convey
the latest research on skin care. All information provided is from an unbiased
Duke University study by Dr. Pindell.
Vitamin C Physiology Vitamin C is not synthesized in the body. It must be
provided by diet Body stores are limited by control mechanisms which allow
amaximum of 1200mg to be absorbed daily. The half life of Vitamin C is 10-20
days, so aftert three weeks Vitamin C is gone in the absence of furtheringestion.
Vitamin C is a major anti-oxidant in the body and is important in mcollagen
Topical Vitamin C We have added a stable aqueous formulation of ascorbic
acid (Vitamin C) to complement the LaCrista skin care line. It absorbs large
amounts of Vitamin C into the skin. The formulation delivers more than 20
times the amount of Vitamin C found in normal skin. These levels cannot
beachieved by diet and are pharmacologic levels.
Photoprotectant Topical Vitamin C is capable of protecting skin against
ultraviolet light exposure. It is equally effective against UVB (290-320
mu) and UVA (320-400 nm). Indeed, it appears to be wavelength independent.
It is clearly not a sunscreen; it has no ultraviolet absorption spectra
in thesetested wavelengths. We believe it is photoprotective because of
its anti-inflammatory properties.
Anti-inflammatory Topical Vitamin C is protective even when it is applied
after photoexposure. It is capable of controlling the inflammatory response
associated with ultraviolet exposure (sunburn).
Reservoir Effect Topical Vitamin C becomes an inherent part of the skin.
It cannot be washed or rubbed off. Our testing shows that it is fully protective
as long as three days after application.
When skin is exposed to ultraviolet light, our measurements show that two-
thirds of the ascorbic acid in skin is destroyed. We believe that ascorbic
acid's role as an anti-oxidant is essential in protecting the skin from
oxidative damage produced by ultraviolet light exposure and the associated
inflammatory reaction. It is believed that this oxidative insult (generation
of oxidative-free radicals) results in damage to other skin constituents
including collagen, elastin, proteoglycan, as well as cell membranes and
nuclear constituents. In time it is believed these changes may result in
connective tissue breakdown (aging and wrinkles) and skin cancer.
By providing pharmacologic levels of ascorbic acid which we can target to
skin by topical application, we hope to interfere with environmental oxidative
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